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KMID : 0615720160330040049
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Jouranl of Korean Acupuncture and Moxibustion society
2016 Volume.33 No. 4 p.49 ~ p.53
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The Effects of Jodeungsan Pharmacopuncture at GB20 on Cognitive Impairment Induced by Focal Brain Injury in Rats
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Hyun Min-Kyoung
Mo Min-Ju
Hwang Doo-Ree
Yang Tae-Jun
Lee Jung-Hun
Lee Eun-Ji
Yoon Tae-Kyung
Youn Dae-Hwan
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Abstract
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Objectives: This research was performed to investigate the effects of Jodeungsan pharmacopuncture( PA-J) of focal brain ischemia induced by middle cerebral artery occlusion(MCAO) in rats.
Methods: The subjects were divided into 4 groups : control, acupuncture , pharmacopuncture PA-J1(11.43 ㎎ / 250 g / 40 ㎕) and pharmacopuncture PA-J2(2.29 ㎎ / 250 g / 40 ㎕). The focal brain ischemia was induced by intraluminal filament insertion into the middle cerebral artery. After 3 days of MCAO, Jodeungsan pharmacopuncture treatment was performed on the GB20, and the day after being treated with pharmacopuncture, the Morris water maze test was carried out on the assigned group. The series of processes were administered 6 times. Thereafter mGluR5, density of neuronal cell and ChAT were measured.
Results: The results were as follows.
1. The distance to target significantly decreased in the 2nd trial of the Acu group on the water maze test for short-term memory.
2. The distance to target significantly decreased in the 4th trial of the PA-J2 group on the water maze test for long-term memory.
3. The intensity of mGluR5 significantly increased in the PA-J1 group compared with the control group.
4. The neuroprotective effect on the hippocampal CA1 significantly increased in the PA-J1 and PA-J2 groups compared with the control group.
5. The density of ChAT in the hippocampal CA1 significantly increased in the PA-J1 and PA-J2 groups compared with the control group.
Conclusions: These results suggest that Jodeungsan pharmacopuncture may improve memory and cognitive impairment and also have neuroprotective effects on focal brain ischemia.
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KEYWORD
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Vascular dementia, MCAO, Jodeungsan, Pharmacopuncture, GB20
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